The company focuses on vitamins, amino acids, plant extracts, sweeteners and other series of products, which have been widely used in food, health food, cosmetics, feed, veterinary medicine and other industries.
Products
High Purity Vitamin K1 Oil (Phytonadione) CAS 84-80-0 | ≥98% for Pharma & Personal Care
Description:
Product Overview
Vitamin K1 (Phytonadione) is a fat-soluble vitamin that plays an essential, well-defined role in human physiology. Its primary function is as a required cofactor for the enzyme γ-glutamyl carboxylase, which is responsible for the post-translational carboxylation of specific glutamic acid residues in several key proteins. This carboxylation is critical for the biological activity of coagulation factors II (prothrombin), VII, IX, and X, as well as the anticoagulant proteins C and S. By activating these proteins, Vitamin K1 is indispensable for the hepatic synthesis of prothrombin and other coagulation factors, thereby playing a central role in the blood clotting cascade. Beyond hemostasis, Vitamin K1 also contributes to bone health by supporting the carboxylation of osteocalcin, a protein involved in bone mineralization and calcium homeostasis.
At Henan Liyin Biotech, we supply high-purity Vitamin K1 in the form of a clear, yellow to yellow-green viscous oil, with a minimum assay of ≥98% (by HPLC). Our product is rigorously manufactured to meet the highest quality standards and is fully compliant with USP, EP, and BP pharmacopoeia specifications. This ensures consistent purity and potency for the most demanding pharmaceutical, nutraceutical, and personal care applications.
- Proven Purity: Each batch undergoes rigorous HPLC assay, heavy metal screening, and microbial testing, with a guaranteed assay of ≥98%.
- Multi-Standard Compliance: Meets USP, EP, and BP specifications, providing global regulatory acceptance for your products.
- Complete Traceability: Every shipment includes a comprehensive Certificate of Analysis (COA) with batch-specific data.
- Flexible Supply: Available in 1kg and 5kg tin can packaging to support your R&D and production needs.
CERTIFICATE OF ANALYSIS | ||||
Product Name | VITAMIN K1（PHYTONADIONE） | Code Name | C004 | |
Specification | Bulk drug(Injection) | Batch Quanity | 140KGS | |
Batch NO. | Package | Aluminum Tin | ||
MFG Date | EXP.Date | |||
Items | Standard 0f USP43 | Result of test | ||
Appearance | A clear,intense yellow,viscous,oily liquid,practically insoluble in water,sparingly soluble in alcohol,miscible with fatty oils. | conform | ||
Identification | Refractive index | 1.523---1.526 | 1.526 | |
UV spectrum | Test solution and std solution exhibit maxima at the same wavelength and absorptivity at 248nm is within 3.0％ | conform | ||
Infrared spectrum | Conformance with standard spectrum. | conform | ||
Reaction 1 | A 1 in 20solution of it in dehydrated Alcohol is neutral to litmus. | conform | ||
Reaction 2 | Test the limit of menadione | conform | ||
Assay(Z and E isomers) | 97.0％—103.0％ | 98.30% | ||
Assay(z isomer) | ≤21.0％ | 18.00% | ||
Conclusion | The product comply with USP43 | |||
packaging
Quality Assurance & Documentation
All batches undergo rigorous quality control, including HPLC assay, heavy metal screening, and microbial testing. We provide complete documentation with every shipment, including Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), and Allergen Statement. Our GMP-certified production ensures batch-to-batch consistency and traceability.
Our Commitment to Quality: Precision in Purity and Isomer Control
At Henan Liyin Biotech, our commitment to quality is reflected in every batch we produce. Take our recent Vitamin K1 batch, for example. While the USP standard requires an assay of 97.0%–103.0%, our batch consistently achieved 98.30% total purity, demonstrating our ability to produce high-potency material suitable for the most demanding pharmaceutical and personal care applications.
What truly sets us apart is our precise control over Z-isomer (cis) content. The Z-isomer is the biologically active form of Vitamin K1, and we maintain it at a controlled 18.00% (well within the ≤21.0% USP limit). This ensures batch-to-batch consistency in biological activity, which is critical for injectable and other sensitive formulations.
Our rigorous quality control extends to physical properties as well. Our product is a clear, viscous oil that meets all USP identification tests, including refractive index (1.526), UV, and IR spectroscopy. This ensures you receive a pure, stable, and fully traceable ingredient for your formulations.
Sourcing Support
We offer flexible packaging options and can provide samples for pre-shipment testing. Our technical team is available to assist with grade selection, application guidance, and custom formulation support — from R&D trials to full-scale commercial production.
Parameters:
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parameter
Specification
product name
Vitamin K1 (Phytonadione)
CAS Number
84-80-0
Molecular Formula
C₃₁H₄₆O₂
Assay (Purity)
≥ 98% (by HPLC)
Appearance
Clear, yellow to yellow-green viscous liquid
Standards
USP, EP, BP
Heavy Metals
≤ 20 ppm
packaging
1kg/tin can, 5kg/tin can
Documentation
Full COA, MSDS, Allergen Statement
Storage Conditions
Store in a cool, dry place, protected from light and oxygen
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Vitamin K1 (Phytonadione) is a fat-soluble vitamin essential for the hepatic synthesis of prothrombin and other blood coagulation factors. It plays a critical role in the blood clotting cascade
and is also involved in bone metabolism and cardiovascular health.
-
Pharmaceutical Preparations: Used in the manufacture of solid dosage forms (tablets, capsules) and injectable solutions for the treatment and prevention of Vitamin K deficiency bleeding.
Dietary Supplements: Incorporated into multivitamin and mineral formulations, often in combination with calcium and Vitamin D for bone health support.
Food Fortification: Added to infant formula, children's food, and medical nutrition products to ensure adequate intake.
Key words:
High Purity Vitamin K1 Oil (Phytonadione) CAS 84-80-0 | ≥98% for Pharma & Personal Care
Function:
Vitamin K1 (Phytonadione) is a fat-soluble vitamin essential for the hepatic synthesis of prothrombin and other blood coagulation factors. It plays a critical role in the blood clotting cascade
and is also involved in bone metabolism and cardiovascular health.
Application：
Pharmaceutical Preparations: Used in the manufacture of solid dosage forms (tablets, capsules) and injectable solutions for the treatment and prevention of Vitamin K deficiency bleeding.
Dietary Supplements: Incorporated into multivitamin and mineral formulations, often in combination with calcium and Vitamin D for bone health support.
Food Fortification: Added to infant formula, children's food, and medical nutrition products to ensure adequate intake.
About Us
Henan Liyin Biotech Co.,Ltd
We are is established in 2024,located in Zhengzhou,on the banks of the Yellow River-the revered “Mother River “of China .As a specialized supplier of human nutrition and animal health products ,the company focuses on a range of products including vitamins ,amino acids ,plant extracts ,and sweeteners,which are widely used in industries ,such as food ,health supplements,cosmetics ,feed and veterinary medicine .By integrating global product resources with the needs of international clients ,Liyin Biotech provides premium products and professional services tailored to each customer .
FAQ
How to contact ?
You can contact with us by Whatsapp:+86 15824830539, the Average Response Time is 0-4h on Work time, <24h on Non-worktime.
For every inquiry, our sales will provide the one-for-one service for you.
How about the payment terms ?
Normal orders: Company account ;Sample/small orders: Paypal(The 5-10% extrafee).About the payment term, we will negotiate alone.
How to get the samples ?
At the first time ,we can provide you the normal product <30g free sample
How to confirm the Product Quality before placing orders?
1st, you can get free samples for some products, just paythe basic cost for us.
2nd,Also you can send the specification or your quest tous, we will customize the products for you.3rd,We emphasis that our whole company make a livingwith organic chemical and customers, we absolutelyimpossible to sale any fake goods, unqualified goods, it isshame! And None False certificate/lie/illegal thing in oursales net!
Which kind of payment do you accept?
- As usually we use company account ,T/T in advance ,or at least 30% T/T in advance ,the balance can be paid by the copy of B/L
- For some countrys we can accept L/C at sight & DP at sight
- For smaples we can use Paypal (The 5-10% extra fees) or other ways
About the payment term, we will negotiate alone.
How about the shipment ?
1>For bulk goods ,we can use contaioner by sea ,1&20 and 1&40 contaioner
2>For urgently and expensive goods ,we can arrange the air lines for customers choose ,or can as customer required
3>For samples or small quantity goods ,we can use Fedex or other express ways
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About Us
As a specialized supplier of human nutrition and animal health products ,the company focuses on a range of products including vitamins ,amino acids ,plant extracts ,and sweeteners,which are widely used in industries ,such as food ,health supplements,cosmetics ,feed and veterinary medicine .
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