Product Overview

Vitamin B12 (Cyanocobalamin) is an essential cobalt-containing water-soluble vitamin that plays a fundamental role as a coenzyme in two critical metabolic pathways: the conversion of methylmalonyl-CoA to succinyl-CoA (a key step in fatty acid and carbohydrate metabolism) and the synthesis of methionine from homocysteine (a vital process for DNA methylation, red blood cell production, and nervous system function).

At Henan Liyin Biotech, we supply high-purity Vitamin B12 in the form of a dark red crystalline powder, with a minimum assay of 98% (97.0%–102.0% per USP) . Our product is manufactured under strict GMP controls and complies with the latest USP-NF standards, ensuring exceptional batch-to-batch consistency and purity. We provide full transparency with a detailed Certificate of Analysis (COA) for every batch, including comprehensive impurity profiling and microbial testing.

Key Physiological & Application Benefits:

Animal Nutrition: In swine, poultry, and aquaculture, Vitamin B12 is indispensable for growth promotion, feed conversion efficiency, and the prevention of deficiency syndromes (e.g., pernicious anemia, poor feathering). Its coenzyme role in methylmalonyl-CoA metabolism is particularly critical for energy utilization from fats and proteins.

Human Health: As an essential nutrient, Vitamin B12 supports normal nerve function, red blood cell formation, and DNA synthesis. It is widely used in dietary supplements (tablets, sublingual drops) and pharmaceutical injections for the management of B12 deficiency and pernicious anemia, with typical dosages ranging from 2.4 to 100 μg per serving.

Why Choose Our Vitamin B12?

Verified Purity: Each batch is rigorously tested for assay (HPLC), related substances, residual solvents (acetone), and microbial limits according to USP-NF 2024 standards.

Complete Traceability: Every shipment includes a comprehensive COA with specific batch data, including manufacturing and expiry dates.

Flexible Supply: Available in packaging from 100g tins to bulk quantities, tailored to your production needs.

Vitamin B12 (Cyanocobalamin) is an essential cobalt-containing vitamin.

 It acts as a coenzyme in two key metabolic pathways: the conversion of methylmalonyl-CoA to succinyl-CoA (important for fatty acid and carbohydrate metabolism) and the synthesis of methionine from homocysteine (crucial for DNA and red blood cell production).

Animal Feed

In swine, poultry, and aquaculture, Vitamin B12 is an essential feed additive that supports growth performance, feed efficiency, and overall flock or herd health. As a coenzyme for methylmalonyl-CoA mutase, it facilitates the utilization of propionic acid (a byproduct of carbohydrate and protein fermentation in ruminants) and is critical for energy metabolism from fats and proteins.

Key Benefits: Prevents deficiency symptoms such as poor appetite, reduced growth rate, and pernicious anemia in young animals. In poultry, it supports feathering and egg production; in swine, it improves weaning weight and reproductive performance.

Recommended Dosage: Typical inclusion rates range from 0.01 to 0.05 mg/kg of complete feed, often in combination with other B-vitamins such as choline, folic acid, and niacin, with which it synergizes to optimize methyl donation and one-carbon metabolism.

Formulation Tip: Due to its high potency, our Vitamin B12 is typically incorporated into feed premixes at very low concentrations. We offer custom dilution and blending options to facilitate even distribution in feed.

Dietary Supplements

Vitamin B12 plays a pivotal role in human health, acting as an essential cofactor for methionine synthase in the conversion of homocysteine to methionine. This process is vital for DNA methylation, red blood cell (erythrocyte) formation, and the maintenance of the myelin sheath that insulates nerve fibers. Deficiency can lead to megaloblastic anemia and neurological disturbances.

Target Applications: Widely formulated into multivitamin tablets, B-complex capsules, sublingual drops, oral sprays, and fortified foods (e.g., plant-based milks, breakfast cereals).

Dosage Range: Typical daily supplementation doses range from 2.4 μg (maintenance) to 100 μg (therapeutic) , depending on the population and product positioning. Higher doses are often used in sublingual or spray formats for enhanced absorption.

Consumer Appeal: Our high-purity, crystalline form ensures excellent stability and bioavailability, making it a preferred choice for brands targeting health-conscious consumers, vegans, and the aging population.

Pharmaceuticals

In the pharmaceutical sector, Vitamin B12 (Cyanocobalamin) is a critical active pharmaceutical ingredient (API) for the treatment and prevention of pernicious anemia and other forms of Vitamin B12 deficiency, particularly in patients with malabsorption syndromes.

Key Applications: Used in the manufacture of sterile injectable solutions (intramuscular or intravenous), which remain the primary treatment modality for severe deficiency.

Critical Quality Attributes: Our product is manufactured with stringent controls over pyrogens, endotoxins, and sterility to meet parenteral-grade requirements. The high purity (≥98%) and low impurity profile are essential for injectable formulations.

Standards: Compliant with USP-NF monographs, ensuring all parameters (identification, assay, related substances, and sterility assurance) meet the rigorous standards required for pharmaceutical use.